Ion chromatography (IC) is an established procedure that allows researchers to separate ions and polar molecules based upon their charge. New IC technologies have increased the resolution and throughput of these instruments, allowing new applications to be serviced.
Chirality plays a critical role in drug efficacy because enantiomers may have vastly different biological, pharmacological and toxicological properties. Smaller particles and the addition of MS detection help speed chiral analysis time and accelerate method development.
As helium becomes a rarer resource for gas chromatography practitioners, hydrogen is filling the void as a viable alternative that can offer superior results. Chromatographers are increasingly choosing to switch to hydrogen, a gas easily and inexpensively produced safely through an on-site generator.
Gas chromatography (GC) remains one of the most important and widely used analytical testing techniques performed today across a number of industries. Harvesting the power of application-specific phases, as opposed to general purpose columns, allows both performance and productivity gains.
FTIR has emerged as a viable alternative to gas chromatography for the qualitative and quantitative analysis of gases. Qualification and quantitation are performed from the wave numbers of the characteristic peaks and peak intensities of the measured gas.
If there was a method for packing material manufacturers to specify shape characteristics and for column manufacturers to inspect incoming materials against those specifications, manufacturing HPLC columns would become more predictable, less costly and exhibit consistent performance. Recent advancements in image analysis could provide the answer.
This article describes a method for the rapid and sensitive detection of 36 CEC analytes in less than 20 minutes per sample. This UHPLC MS/MS method was developed on an Agilent 1290 Infinity LC system coupled to an Agilent 6460 Triple Quadrupole LCMS system using both positive and negative electrospray ionization.
The flexibility to perform separations without pH, temperature or mobile phase restrictions arms chromatographers with powerful tools for tackling tough separations. The right combination of stationary and mobile phase is critical for generating the well-defined, sharp peaks that allow shorter run times.
Sampling using sorbent tubes for analysis by thermal desorption gas chromatography is ideal for a wide range of applications, from monitoring industrial air to odor profiling of foods. However, for those new to the area, the options available can make it difficult to decide how best to proceed.
A multitude of performance factors including dense gas CO2, small particle columns and mass spectrometry with UV detection are speeding up chiral separation methods development. Chirality plays a critical role in drug efficacy because enantiomers may have vastly different biological, pharmacological and toxicological properties.
Waters Corp., Milford, Mass., has published an all-new 212-page Beginner's Guide to Solid Phase Extraction (SPE). The book includes chapters on terms and calculations, methods development, troubleshooting, understanding how liquid chromatography makes SPE powerful, benefits of SPE, an extensive glossary of terms and numerous applications.
Concurrent solvent recondensation–large volume splitless injection meets the EPA’s low detection limits for water analysis, while also reducing sample preparation time by more than one hour. This injection method produces a pressure surge from the vaporizing solvent, forcing the analytes onto the pre-column.
MEMS–Based Systems Solutions (MBSS) are the integration of MEMS front ends, including sensors, actuators and or structures, with signal processing vis-à-vis ASIC, embedded software in the microprocessor-based ASIC, energy management/storage and network connectivity, either wired or wireless.
The development and commercialization of new medical drugs is a complex and costly process, but increasing pressure is being placed on drug companies to accelerate the timeline from discovery of new drugs. The pharmaceutical industry continues to demand ever more advanced products aimed at improving health and the quality of modern-day life.
Ultra High Performance Liquid Chromatography (UHPLC) is an increasingly popular technique. By using a combination of sub-2 μm particles and instrumentation capable of withstanding high pressures and maintaining peak shape, UHPLC allows for higher sensitivity, resolution and speed than traditional HPLC.
The presence of potentially toxic elements and compounds in foodstuffs is of intense public interest, and so food producers as well as regulators require rapid, reliable screening methods to accurately determine the levels of such contaminants in food and drink.