If there was a method for packing material manufacturers to specify shape characteristics and for column manufacturers to inspect incoming materials against those specifications, manufacturing HPLC columns would become more predictable, less costly and exhibit consistent performance. Recent advancements in image analysis could provide the answer.
This article describes a method for the rapid and sensitive detection of 36 CEC analytes in less than 20 minutes per sample. This UHPLC MS/MS method was developed on an Agilent 1290 Infinity LC system coupled to an Agilent 6460 Triple Quadrupole LCMS system using both positive and negative electrospray ionization.
The flexibility to perform separations without pH, temperature or mobile phase restrictions arms chromatographers with powerful tools for tackling tough separations. The right combination of stationary and mobile phase is critical for generating the well-defined, sharp peaks that allow shorter run times.
A multitude of performance factors including dense gas CO2, small particle columns and mass spectrometry with UV detection are speeding up chiral separation methods development. Chirality plays a critical role in drug efficacy because enantiomers may have vastly different biological, pharmacological and toxicological properties.
VICI Valco’s nickel-clad tubing is available with fused silica (FS) tubing, PEEK tubing band polyimide-coated fused silica tubing. These selections make the nickel-clad tubing suited for HPLC and UHPLC use.
Agilent Technologies’ 2013 Essential Chromatography and Spectroscopy Catalog is divided into five sections to help the reader easily navigate the company’s growing portfolio, which includes general chromatography, sample preparation, GC and GCMS, LC and LCMS and spectroscopy. This edition of the catalog contains CrossLab products for use with other manufacturers’ instruments. It also includes details about electrochemistry meters and supplies, Captiva syringe filters, Ultra Inert and application-specific GC columns, LC biomolecule and Poroshell 120 columns and OneNeb nebulizer for ICP-OES and MP-AES.
Cerilliant offers Certified Spiking Solutions of nicotine metabolites norcotinine and trans-3-hydroxycotinine, as well as nicotine nitrosamines NNN, NNK and NAB at concentrations of 1.0 mg/mL in methanol for each solution standard. These certified reference solutions can be used as Snap-N-Spike starting materials in the laboratory’s matrix of choice for preparation of calibrators and controls in nicotine testing and other clinical or diagnostic applications by LCMS or GCMS.
Agilent Technologies’ OpenLAB Data Store with Lab Applications is an out-of-the-box solution for smaller laboratories that provides secure central storage of the data produced by the proprietary OpenLAB chromatography data systems. The software is designed to streamline the management of laboratory operations, assets and regulatory compliance.
IonBench’s furniture offerings are dedicated to bringing quiet, vibration-free solutions to mass spectroscopy and liquid chromatography. The MS Bench incorporates a soundproofing solution with anti-vibration features in a solidly-built bench that can reduce system footprint by 30%.
Thermo Fisher Scientific’s Syncronis HPLC columns are available with 3 mm particle size. This particle size complements the existing 1.7 and 5 µm particle sizes.
Protea Biosciences Group’s Amplus wide-pore core shell HPLC columns are a line of liquid chromatography columns specifically designed for intact proteins analysis. This family of HPLC silica-based columns employs core shell technology combined with a specific porosity designed to facilitate proteins separation, including those with high molecular weight.
Isolation Technologies’ new, interactive online tool shows instrument manufacturers and laboratory scientists a broad range of empty column hardware and accessories available from IDEX Health & Science. The interactive brochure as a enables the user to see the most popular in-stock hardware and select by specification.
Fortis Technologies is expanding its current range of liquid chromatography products with the launch of its BIO HPLC and UHPLC Columns. Centered around a 300A silica matrix, the phases are designed specifically for bioanalysis of peptides and proteins, where a larger pore size is required to provide retention and selectivity.
Thermo Fisher Scientific’s Acclaim Trinity Q1 HPLC columns are designed to facilitate high-resolution and high-throughput trace analysis of the herbicides diquat and paraquat in plants by LCMS.
Thermo Fisher Scientific and METTLER TOLEDO have collaborated to provide a combined Titration/Ion Chromatography (IC) system designed to provide a fast, accurate and integrated solution for fully automated water analysis for laboratories testing the quality of drinking, surface or ground water.
Thermo Fisher Scientific’s UltiMate 3000 XRS UHPLC system offers UHPLC capabilities in solvent delivery and sample handling with a range of detector options for high-throughput laboratories.
Restek’s USLC column set represents a range of reversed phase selectivity with just four stationary phases: aqueous C18, IBD, biphenyl, and PFP propyl.
Bruker’s nano-Advance UHPLC system for capillary and nano-flow LCMS applications further enhanced the company’s integrated solutions for proteomics.
In partnership with Perfinity Biosciences, Shimadzu Scientific Instruments has released the Perfinity Integrated Digestion Platform (IDP).
Asynt has supplied a European Contract Research Organization (CRO) with a custom heating block system to assist chemists analyzing the thermal stability of multiple samples being prepared for its commercial compound libraries.
Agilent Technologies' 1220 Infinity LC system with DAD brings UHPLC analytical power with diode-array detection to users who do not need the flexibility of a modular system, but still require the highest quality at a low price.
LC pump engineers have undertaken the formidable task of reaching 20,000 psi and above, rethinking and possibly revolutionizing the pump design.
Waters’ TruView LCMS Certified Vials, a line of low-adsorption sample vials, are certified for LCMS/MS analyses where analyte concentrations are on the order of ng/mL or pg/mL and where analytical sensitivity and accuracy are critical.
Thermo Fisher Scientific provides web-based chromatography assistance to chromatographers looking to optimize methods with the latest column technologies with the HPLC Method Development Calculator.